The Seasiders will be without Charlie Goode, who has returned to Brentford for scans on his hamstring injury, while the likes of Andy Lyons, Morgan Rogers and Josh Bowler will be pushing to start.
Here’s how we think Mick McCarthy’s side might line up against the Millers...
1. In the frame
Josh Bowler will be desperate to start after making a big impact off the bench in midweek Photo: CameraSport - Dave Howarth
2. GK - Chris Maxwell
Produced a couple of crucial stops against Huddersfield in midweek, including one wonder save. Photo: CameraSport - Dave Howarth
3. RB - Andy Lyons
Callum Connolly did a good job at both right-back and centre-back after being forced to shift over, but Lyons brings a bit more going forwards. Photo: CameraSport - Dave Howarth
4. CB - Curtis Nelson
The Seasiders will need Nelson's aerial ability in the absence of Charlie Goode and Gary Madine. Photo: CameraSport - Dave Howarth
5. CB - Jordan Thorniley
Mick McCarthy confirmed Thorniley was just not selected in midweek after the defender was left out of his squad. But with Goode injured, he would be a natural replacement. Photo: CameraSport - Dave Howarth
6. LB - James Husband
Could always be an option at centre-back, with Dom Thompson perhaps returning to the side. But I expect Hubby to remain at his favoured left-back. Photo: CameraSport - Dave Howarth